Novel melanoma antigen peptide and uses thereof

The invention relates to peptides derived from the MELOE antigen for therapeutic vaccination against cancer. A phase I clinical trial for ex-vivo […]

Hydrophobically modified antisense oligonucleotides comprising a cetal

The present invention concerns an oligonucleotide modified by substitution at the 3’ or the 5’ end by at least triple alkyl chain or at least one […]

Ex vivo gene therapy based vaccine with nucleic acid molecule encoding

The present invention relates to a method of treating a B-cell malignancy in a subject using a vaccine composition comprising a population of […]

Mitoception: novel method for the intracellular transfer of isolated

The present invention relates to a method for the intercellular transfer of an amount of mitochondria isolated from a population of donor cells into a […]

Cdc25a phosphatase inhibitor for use in thetreatment of a drug

The invention relates to a CDC25A phosphatase inhibitor for use in the treatment of drug resistant cancer or for use in the prevention of tumor […]

Methods for the diagnosis and treatment of t cell-lymphomas

T-cell lymphomas are a heterogeneous group of malignancies involving T lymphocytes and generally characterized by a poor prognosis. Among them, […]

Methods and composition to identify and treat subjects resisting to

The present invention relates to a method for treating a subject suffering from a cancer comprising a step of administering said subject with a […]

Garp as a biomarker and biotarget in t-cell malignancies

The present study of the regulatory T phenotype of Sézary cells led to the discovery of the expression of GARP (LRRC32) by Sézary cells. GARP has […]

Methods for the diagnosis and treatment of acute lymphoblastic

The present invention relates to a method of treating acute lymphoblastic leukemia in a patient in need thereof comprising administering to the […]

Novel b-raf inhibitors devoid of rapid metabolism and of binding to

The present invention relates to N-(3-(5-(pyrimidin-4-yl)thiazol-4-yl)phenylsulfonamide compounds which are useful as inhibitors of protein kinases, […]