Sphingosine kinase 2 inhibitors in combination with immune checkpoint

Immune checkpoint blockade therapy is based on the inhibition of the tumor-mediated suppression of anticancer immune responses. However, the efficacy […]

A lyn kinase activator for the treatment of braf inhibitor-resistant

The present invention relates to method and composition for treating melanoma. The inventors have shown that a decrease in LYN expression, in melanoma […]

Sphingosine kinase 1 a new tumor target for enhancing the potency of

The present invention relates to methods for enhancing the potency of the immune checkpoint inhibitors. In particular, the present invention relates […]

Methods and compositions for treating melanoma

The present invention relates to a method and composition for treating melanoma. More particularly, inventors have shown that high expression of USP14 […]

Prognosis and treatment of patients suffering from prostate cancer

The invention relates to methods for predicting the outcome of a patient suffering from prostate cancer and methods for the treatment of prostate […]

Stratification of melanoma patients for immune checkpoint inhibitor

Immune checkpoint inhibitors (ICI) have revolutionized therapy for advanced cancer, however many patients still do not respond to treatment. However, […]

New biomarker for stratifying cancer patients for immune checkpoint

The present invention relates to use of soluble CD27 as a biomarker to predict the reponse to an immune checkpoint inhibitor treatment. Inventors have […]

New biomarker for prognosis and treatment of patients with melanoma

The present invention relates to a method and composition for treating melanoma, aggressive/invasive melanoma, metastatic melanoma or melanoma […]

New method using imaging analysis for assisting with prognosis of

The present invention relates to a method for assisting with lymphoma prognosis. The prognosis of therapeutic response of patients with lymphoma is […]

Determining whether a patient suffering from lung cancer is eligible

Lung cancers consist of two major histological types, non-small-cell lung carcinoma (NSCLC) and small-cell lung carcinoma. NSCLC consists of squamous […]