Glycated Hb was measured and compared between five healthy donors (AA), seven non-diabetic and non-transfused homozygous SCD patients (SS) and five […]

Refrigerated storage of red cell concentrates (RCC) for transfusion is associated with the accumulation of various alterations to the red blood cells […]

The clinical severity of ?-hemoglobinopathies is alleviated by the co-inheritance of genetic mutations causing a sustained fetal ?-globin chain […]

Glycosylphosphatidylinositol (GPI) is a glycolipid that anchors more than 150 proteins to the cell surface. Pathogenic variants in several genes that […]

Acute chest syndrome (ACS) is a common and potentially lethal form of acute lung injury in sickle cell disease (SCD). Because pathophysiology remains […]

The present invention relates to anti-protease nexin-1 (PN-1) conformational single domain antibodies and uses thereof in particular in the […]

The present invention relates to a genetically modified hematopoietic stem cell(HSC) comprising, in at least one ?-globin gene comprised in the genome […]

The present invention relates to methods and pharmaceutical compositions for the treatment of myeloproliferative disorders in patients presenting a […]

The thrombogram of FVIII-KO mice displays a prolonged time to peak and a reduced peak thrombin. The addition of the neutralizing anti-protease nexin-1 […]

The normal development of red blood cells requires a coordinated synthesis of the hemoglobin (Hb) subunits, the ?- and ?-globins in the case of adult […]