Screening and characterization of new histone deacetylase inhibitors

Using BRET technology, we designed a method to measure histone acetylation in living cells. Cells are transfected with a vector coding for a […]

Transgenic mouse model for myotonic dystrophy: dmsxl carrying

This transgenic mice model contains large human genomic DNA sequence carrying the DMPK gene with very large repeat (>1200 CTG). They show […]

Rat anti-mouse cd90.2 (mouse thy-1.2) (several clones)

A collection of rat monoclonal antibodies recognizing Thy-1-2-associated epitopesH154-530 ; H140-226 ; H154-18 ; H154-470 ; H154-238 (all IgM,kappa) […]

Mouse anti-human adam10 (a disintegrin and metalloprotease domain 10)

Mammalian disintegrin-metalloproteasem Kuzbanian protein homolog, CDw156, Disintegrin and metalloproteinase domain-containing protein 10 […]

Mouse anti-rat cleaved snap-25 (botulinum neurotoxin e)

This antibody detects exclusively SNAP-25 cleaved by botulinum neurotoxin E and not the full-length protein […]

Trpv2 as a new therapeutic target to modulate blood brain barrier

The present invention relates to a method for modulating blood-brain barrier (BBB) in a subject comprising a step of administering said subject with a […]

Gene therapy coding for anti-tau nanobody to treat rare tauopathies

The invention relates to generation, optimization and characterisation of VHH targeted against Tau MTBD (microtubule-binding domain) with high […]

New molecules for neurodegenerative pathologies : indirect ?-secretase

The present invention is directed to novel compounds and pharmaceutically acceptable salts or solvates thereof, and their use. […]

Trek1/trek2 as targets for the treatment of migraine

Inventors have found that the MT mutation puts an alternative start codon in frame which leads to the translation of a second TRESK fragment. […]