Methods and pharmaceutical compositions for enhancing cd8+t

Targeting immune checkpoints, such as Programmed cell Death 1 (PD1), has improved survival in cancer patients by unleashing exhausted CD8+ T-cell […]

Inhibitor of the heterochromatin protein 1 (hp1) for modulating th

The present invention relates to a treatment of Th cell-associated disorders. Here, theinventors The inventors show that Treg-dependent suppressive […]

Indole-3-propionic acid as an important contributor to viral infection

The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, the inventors used […]

A composition comprising lipid nanoparticles and an antifungal polyene

The present invention relates to a composition comprising an aqueous phase, a polyene antifungal and lipid nanoparticles which are dispersed in the […]

Antisense oligonucleotides and ceftriaxone in the strategy against

The present invention relates to the treatment of infections due to antibiotic-resistant bacteria. Antimicrobial resistance (AMR) has been observed at […]

New 6-6 or 5-6 fused bicyclic compounds comprisingpyrimidine useful in

The present invention relates to new specific 6-6 or 5-6 fused bicyclic compounds comprising pyrimidine or pyridine useful in the prevention and/or […]

New clofoctol formulation

The invention concerns a new galenic formulation of CFT (clofoctol) allowing the administration of this antibiotic in aerosol form with the objective […]

Targeted-antibacterial-plasmids combining conjugation andcrispr /cas

The global emergence of drug-resistant bacteria leads to the loss of efficacy of our antibiotics arsenal and severely limits the success of currently […]

Aerosol composition for pulmonary delivery of flagellin

The present invention arises from a formulation study in order to define the best excipients including buffer, surfactant, sugar and amino acid to […]

Gram-negative bacteria efflux pump inhibitors

Antimicrobial resistance is a global problem, rendering conventional treatments less effective and requiring innovative strategies to combat this […]