Hydrophobically modified antisense oligonucleotides comprising a cetal

The present invention concerns an oligonucleotide modified by substitution at the 3’ or the 5’ end by at least triple alkyl chain or at least one […]

Nanoparticle based glue, biocompatible sealant for surgery

The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention […]

Pharmacologically active microcarriers for efficient integration of

This invention results from Pharmacologically Active Microcarriers (PAM) which are based on a biocompatible and biodegradable material. These […]

Targeting the secreted ige poly-a signal allows specific inhibition of

Immunoglobulins (Ig) are expressed either on the surface of B cells or as secreted antibodies by plasma cells that represents the final stage of B […]

Methods for improving relaxation of striated myocytes

The Inventors developed conditions allowing to efficiently detect differences in cardiomyocytes relaxation phases associated with increased […]

Methods of treating heart failure

Worldwide, 1% to 2% of the general adult population have heart failure (HF), which is accompanied by reduced quality of life, high morbidity, […]

Lipopeptide compound for the treatment of pain disorder

The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of […]

Allele-specific silencing therapy for dynamin 2-related diseases

The invention relates to an allele specific siRNA able to silence the expression of only one allele of a heterozygous DNM2 gene, for treating diseases […]

Factor h fragment for use as an anti-angiogenic agent

The invention relates to a complement factor H fragment for use in the therapy and/or prophylaxis of a disease involving neovascularization.POC in […]

Methods for expanding a population of alveolar macrophages in a long

The present invention relates to methods for expanding a population of alveolar macrophages in a long term culture. In particular, an object of the […]