Targeted-antibacterial-plasmids combining conjugation andcrispr /cas

The global emergence of drug-resistant bacteria leads to the loss of efficacy of our antibiotics arsenal and severely limits the success of currently […]

Aerosol composition for pulmonary delivery of flagellin

The present invention arises from a formulation study in order to define the best excipients including buffer, surfactant, sugar and amino acid to […]

Gram-negative bacteria efflux pump inhibitors

Antimicrobial resistance is a global problem, rendering conventional treatments less effective and requiring innovative strategies to combat this […]

Method for modulating the differentiation and functions of human

Type 1 conventional dendritic cells (cDC1s) and plasmacytoid dendritic cells (pDCs) are thought to be critical for anti-tumor or antiviral immunity. […]

New adjuvant to improve the innate immunity

The present invention relates to the field of adjuvant and vaccination. In the present study, the inventors investigate whether P1, in addition to […]

Modulating the expression and/or activity of gas7 for modulating viral

Macrophages (MØ) are critical for the detection and clearance of pathogens and yet also serve as replication niches for multiple infectious agents. […]

Alphavirus nsp3 helical tubular scaffolds

Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current […]

New method to treat infectious diseases

The present invention relates to the treatment of infectious diseases. In this study, the inventors identified the potential protective mechanisms […]

Hepcidin antagonists for use in the treatment of inflammation

The present invention relates to a hepcidin antagonist for use in the treatment of inflammatory diseases. TLR4-dependant intestinal hepcidin induces […]

Methods for the treatment of th2-mediated diseases

Voltage-dependent calcium channels (Cav1) contribute to T-cell activation. The inventors previously showed that Th2 cells co-express Cav1.2 and Cav1.3 […]