Trpv2 as a new therapeutic target to modulate blood brain barrier

The present invention relates to a method for modulating blood-brain barrier (BBB) in a subject comprising a step of administering said subject with a […]

Gene therapy coding for anti-tau nanobody to treat rare tauopathies

The invention relates to generation, optimization and characterisation of VHH targeted against Tau MTBD (microtubule-binding domain) with high […]

Method to restore or improve cognitive functions

The present invention relates to the field of memory and cognitive functions. Here the inventors show that memory stimulations induce autophagy in the […]

Targeting myeloperoxidase overcomes cytarabine resistance in human

Chemotherapy commonly alters cellular redox balance and increases the oxidative state. Recent studies have reported that chemoresistant cells have an […]

New molecules for neurodegenerative pathologies : indirect ?-secretase

The present invention is directed to novel compounds and pharmaceutically acceptable salts or solvates thereof, and their use. […]

Enhancement of 5-fluorouracil cytotoxicity by pyridoxal 5’-phosphate

The invention relates to methods and pharmaceutical compositions for treating cancer in a subject in need thereof. The inventors thought that low […]

Use of fzd7 inhibitors for the treatment of retinal neovascularization

Retinal ischemia and abnormal blood vessels growth are major determinants in the pathogenesis of retinopathy of prematurity (ROP) and proliferative […]

Inhibition of nicotinamide phosphoribosyltransferase (nampt) for the

The present invention relates to a method for treating a subject suffering from melanoma resistant by administering to said subject an inhibitor of […]

Methods of treating heart failure

Worldwide, 1% to 2% of the general adult population have heart failure (HF), which is accompanied by reduced quality of life, high morbidity, […]

Methods of enhancing the potency of incretin-based drugs in subjects

The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal […]