Selective pharmacological inhibition of epac1 for the treatment of

The present invention relates to the treatment of idiopathic pulmonary fibrosis. Today, there is no cure for IPF. The inventors showed that EPAC1 […]

Methods and compositions for treating cell senescence accumulation

The inventors have surprisingly demonstrated that GD3 positive senescent cells inhibit NK cell in vitro and in vivo while GD3 negative senescent cells […]

Use of shp2 inhibitors for the treatment of insulin resistance

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because […]

Methods and pharmaceutical compositions for the treatment of chronic

The present invention relates to methods and pharmaceutical compositions for the treatment of chronic kidney disease. The inventors used the CMap […]

Use of pi3kc2¿ inhibitors for the preservation of vascular

Ischemic conditions are a leading cause of death for both men and women. Ischemia, a condition characterized by reduced blood flow and oxygen to an […]

Neutralizing granzyme b for providing cardioprotection in a subject

The present invention relates to a method for providing cardioprotection in a subject who experienced a myocardial infarction comprising administering […]

Methods and compositions for treating asthma and allergic diseases

The present invention relates to allergy field. Several independent groups have recently investigated the implication of PCSK9 on inflammation and […]

Novel melanoma antigens

The invention relates to melanoma antigen named MELOE and their use for preventing, treating and diagnosing melanoma. […]

Anti-cathepsin d human antibody for triple negative breast cancer

Inventors have generated two human anti-cath-D scFv fragments cloned in the human IgG1 ??format (F1 and E2) that efficiently bind to human and mouse […]

Triarylpyridine compounds and use thereof for treating cancer

The invention relates to new bis-triazole 2,4,6-triarylpyridines compounds and their use in the field of oncology, in particular in the prevention […]