Mouse anti-mouse i-ak (mouse mhc classe ii allodeterminants) (several clones)

A collection of 17 mouse allospecific monoclonal antibodies raised in the A.TH (Is) anti-A.TL (Ik) combination.

Interest / Relevance: These monoclonals identify all the major allotopes of the I-Ak molecule and define several major epitope region expressed by the alpha and/or beta subuhits of the I-Ak molecule

Scientist's name: Michel PIERRES
Philippe Naquet (CIML, U631)

Publications:

M. Pierres et al. Distinct epitopes on Ik gene products identified by monoclonal antibodies Eur. J. Immunol. (1980), 10 : 950-957.
M. Pierres et al. Clonal analysis of B- and T-cell responses to Ia antigens. I. Topology of epitope regions on I-Ak and I-Ek molécules analyzed with 35 monoclonal antibodies. Immunogenetics (1981) 14:481-495

Reference:

RT00338

Type of research tool: Antibodies

Therapy area(1): Immunology

Uses(1): Academic Research

Uses(2): Proof of concept in vitro

Uses(3): Proof of concept in vivo

Uses(4): Industry Research (screening, tox.studies, bioreactor, ...)

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Clones available: 40.B, 39.A, 8.A, 40.G,, 39H, 40.L, 40.F, 4O.N, 40.A, 39.B, 40.M, 39.E, 8.C, 8.B, 39.C, 40.J, 39.F, 39.J

Isotype: lgG2a

Source: Mouse

Specificity: Mouse

Immunogen Seq ID: Spleen cells, thymocytes or Concanavalin-A-activated spleen cells

Know Cross Reactivity: H-2 haplotypes : b,d,r,& v (40.B)
b,d,f,p,q,u,& v (39.A)
b,d,p,& q (8.A)
b,d, & p (40.G)
b, & d (39.H)
f & u (40.L, 40.F)
f, r, &u (40.N, 40.A,39.B, 40.M, &39.E)
r (39.J)
none : (8.C, 8.B, 40.J, 39.C, & 39.F)

Depositor: Michel PIERRES

FBS: 10%

Rare disease: No

Last update: 11/09/2024

Mouse anti-mouse i-ak (mouse mhc classe ii allodeterminants) (several clones)

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