The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal […]

The invention related to metabolically stable Apelin analogs and their use for the prevention or the treatment of diseases mediated by the apelin […]

The present invention relates to methods and pharmaceutical compositions for the treatment of fibrosis. In particular, the present invention relates […]

The present invention relates to methods of the treatment and diagnosis of bone mineral density related disorders. More particularly, the present […]

The present invention relates to a method for treating skin afflictions in a subject comprising a step of administering said subject with a […]

Kallikrein proteolytic cascade plays a crucial role in various skin diseases. A series of coumarinic derivatives were identified with IC50 in the […]

The clinical severity of β-hemoglobinopathies is alleviated by the co-inheritance of genetic mutations causing a sustained fetal γ-globin chain […]

Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because […]

The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) […]

This study demonstrates the pivotal role of the local PPAR-gamma agonist system in maintaining podocyte quiescence and orchestrating the global […]