Methods and compositions for predicting and treating uveal melanoma

Here, in multi-scale analyses using single-cell RNA sequencing of six different primary uveal melanomas, inventors uncover a previously unrecognized intratumor heterogeneity at the genetic and transcriptomic level. They identify distinct transcriptional cell states and diverse tumor-associated populations in a subset of primary uveal melanomas.

Keywords: RNA signature, Prognosis, Uveal Melanoma, Intratumor heterogeneity
Patent Application number: EP20 306 384.7 on 16/11/2020
Cell Death Differ. 2021 Jun 28 Pandiani et al Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease. DOI: 10.1038/s41418-020-00730-7 Prog Retin Eye Res 2021 Apr 13 Strub et al Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology DOI: 10.1016/j.preteyeres.2021.100968

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