Establishment of redifferentiated cells after treatment of neoplastic invasive cell lines with curcumin

When undifferentiated, invasive neoplastic cell lines are treated with an optimal time / concentration combination of curcumin (under conditions producing dramatic cell death), a small proportion of surviving cells can undergo a process of redifferentiation. These clones of redifferentiated cells, together with the original tumor cells, could represent interesting biological tools for both academic research (onco-immunology, genetics / epigenetics) and industry research (for example design of cancer vaccines).

Interest / Relevance: The proof of concept has been established in vitro (in culture) on an invasive, undifferentiated sarcomatoid rat mesothelioma cell line (M5-T1) (see attached figure). Extension of this protocol to other types of experimental and human malignant tumor cell lines is in process.
Keywords: Redifferentiation , Neoplastic cells , Epithelial cells , Phytochemicals
Scientist's name: Daniel POULIQUEN
Publications:
- Roulois D Deshayes S Guilly MN Nader JS Liddell C Robard M Hulin P Ouacher A Le Martelot V Fonteneau JF Grégoire M Pouliquen DL. Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs DNMTs and 5-hydroxymethylcytosine. Oncotarget (2016) 7(23) 34664-34687.
- Pouliquen DL
Nawrocki-Raby B Nader J Blandin S Robard M Birembaut P Grégoire M. Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma. Oncotarget (2017) doi : 10.18632/oncotarget.15744.

Reference:

RT00495

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Samples/Models available: Rat (experimental biocollection registered in Migratech "cell lines")
Rare disease: No
Last update: 11/09/2024

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