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Novel b-raf inhibitors devoid of rapid metabolism and of binding to

The present invention relates to N-(3-(5-(pyrimidin-4-yl)thiazol-4-yl)phenylsulfonamide compounds which are useful as inhibitors of protein kinases, […]

Methods and composition to identify and treat subjects resisting to

The present invention relates to a method for treating a subject suffering from a cancer comprising a step of administering said subject with a […]

New strategy targeting stroma/tumor cell crosstalk to treat a cancer

In this study, the Inventors report that CD9 is a key component of PC-associated CAFsderived ANXA6+-EVs. They determined that CD9 is expressed by […]

Mesenchymal stem cell derived extracellular vesicles loaded with at

Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal cavity. The occurrence of […]

Cd38 as a biomarker and biotarget in cell-lymphomas

T-cell lymphomas are a heterogeneous group of malignancies involving T lymphocytes and generally characterized by a poor prognosis. Among them, […]

Methods and compositions for treating triple negative breast cancer

Inventors analyzed the prognostic value of tumor and stromal-derived SPARC in a large series that included 148 non-metastatic TNBC patients with a […]

Method for diagnosing colorectal cancer

The present invention relates to the diagnosing of colorectal cancer. The inventors have thus designed an efficient, rapid and cost-effective method […]

Methods for improving the efficacy of hdac inhibitor therapy and

Investigating the impact of Tau protein expression in cancer cell lines, Inventors have demonstrated that the Tau expression is associated with an […]

Early and non-invasive method for assessing a subject’s risk of

In the present invention inventors perform studies on extracellular vesicles isolated from urine samples to assess the biomarker potential of measures […]

New biomarkers of alcohol use disorders

The present invention relates to a method for predicting alcohol use disorder. The objective of this study was to validate the possibility of […]

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