Immunotherapy has transformed cancer treatment but often struggles with solid tumors due to immune resistance from the tumor microenvironment (TME). […]

Melanoma cell plasticity plays a key role in the acquisition of resistance to therapy. TRIM24/TIF1α, which encodes for the tripartite […]

The Inventors herein demonstrate that CD39 is a relevant therapeutic target in B-celllymphoma, in particular Follicular Lymphoma (FL), Diffuse Large […]

The present invention relates to the treatment of brain or neurologic disorders. In this study, the inventors hypothesized that a Fc receptor (FcRn) […]

Familial adenomatous polyposis (FAP) patients harbor mutations in the APC gene and will develop adenoma and early colorectal cancer. Taking biopsies […]

Targeting immune checkpoints, such as Programmed cell Death 1 (PD1), has improved survival in cancer patients by unleashing exhausted CD8+ T-cell […]

The present invention relates to a treatment of Th cell-associated disorders. Here, theinventors The inventors show that Treg-dependent suppressive […]

The present invention relates to a method of treating acute lymphoblastic leukemia in a patient in need thereof comprising administering to the […]

The present invention relates to an antibody, which is capable of binding to theNeuromedin N long fragment, and Neurotensin long fragment with high […]

The present invention relates to a composition comprising an aqueous phase, a polyene antifungal and lipid nanoparticles which are dispersed in the […]